Developing non-mammalian models for thrombosis research
Thrombosis, the pathological formation of blood clots within blood vessels, remains a formidable medical challenge associated with cardiovascular diseases and strokes. Despite extensive research efforts, many facets of thrombosis initiation, propagation, and resolution remain elusive. Traditional mammalian models have been instrumental in advancing our understanding of thrombotic processes but are accompanied by limitations such as high cost, ethical considerations, and genetic homogeneity. In recent years, there has been a heightened interest in exploring non-mammalian models to complement existing research paradigms and uncover novel insights into thrombosis.
Among non-mammalian models, zebrafish (Danio rerio) have emerged as a promising organism for thrombosis research, offering unique advantages that can significantly contribute to our understanding of thrombotic mechanisms.
Investigating the phenotypic and functional profiling of immune cells represents a fundamental endeavour in immunological research, offering valuable insights into the intricate orchestration of immune responses. This multifaceted approach involves the systematic characterisation of immune cell populations based on their surface markers and effector functions, providing a nuanced understanding of their roles in health and disease.
