Publications

You can find the full list of publications on Professor Gavins' Google Scholar Profile or on PubMed.

(2024)Building an Adverse Outcome Pathway Network for COVID-19.

Nymark P, Clerbaux LA, Amorim MJ, Andronis C, de Bernardi F, Bezemer GFG, Coecke S, FNE Gavins, Jacobson D, Lekka E, Margiotta-Casaluci L, Martens M, Mayasich SA, Mortensen HM, Kim YJ, Sachana M, Tanabe S, Virvilis V, Edwards SW, Halappanavar S. Front Syst Biol. 6;4:1384481. Link

(2024)Exploring the Role of Platelets in Virus-Induced Inflammatory Demyelinating Disease and Myocarditis.

Ahmad I, Omura S, Sato F, Park AM, Khadka S, FNE Gavins, Tanaka H, Kimura MY, Tsunoda I. Int J Mol Sci. 25:3460. Link

(2024)Annexins-a family of proteins with distinctive tastes for cell signaling and membrane dynamics.

V Gerke, FNE Gavins, M Geisow, T Grewal, JK Jaiswal, J Nylandsted, U Rescher.

Nat Commun. 15:1574. Link

(2023)Report from the 2023 workshop on endothelial permeability, edema and inflammation.

D Vestweber, L Claesson-Welsh, DM McDonald, T Williams, MA Schwartz, J Scallan, FNE Gavins, J Van Buul, J Gamble, M Vadas, BH Annex, SR Messe, M Perretti, H André, N Ferrara, T Hla, S Nourshargh, M Simons.

Nat Cardiovascular Research 2:1120-1124. Link

(2023)Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease.

EM Sparkenbaugh, MW Henderson, MD Miller-Awe, C Abrams, A Ilich, F Trebak, N Ramadas, SA Vital, D Bohinc, K Bane, C Chen, M Patel, M Wallisch, T Renné, A Gruber, B Cooley, D Gailani, M Kasztan, GM Vercellotti, JD Belcher, FNE Gavins, EX Stavrou, NS Key, R Pawlinski.

Blood.2022017074. Link

(2023)Regulating Neutrophil PAD4/NOX-Dependent Cerebrovascular Thromboinflammation.

Ansari J, Vital SA, Yadav S, FNE Gavins

International Journal of Biological Sciences 19 (3), 852-864. Link

(2022)Bryostatin-1 Attenuates Ischemia-Elicited Neutrophil Transmigration and Ameliorates Graft Injury after Kidney Transplantation.

F Becker, L Kebschull, C Rieger, A Mohr, B Heitplatz, V Van Marck, U Hansen, J Ansari, S Reuter, B Strücker, A Pascher, JG Brockmann, T Castor, JS Alexander, FNE Gavins

Cells. 11 (6), 948. Link

(2022)The Spectrum of Acute Cerebrovascular Disease in Patients with COVID-19.

R Triay, P Buchhanolla, A Gaudet, V Winter, A Gaudet, M Faraji, E Gonzalez-Toledo, H Siddaiah, HH Cuellar-Saenz, S Bailey, V Javalkar, RMS Riel-Romero, RE Kelley, FNE Gavins, J Ansari.

Biomedicines. 10 (2), 435. Link

(2022)COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease - 3rd CIAO AOP Design Workshop

LA Clerbaux, N Amigó N, MJ Amorim, A Bal-Price, S Batista Leite, A Beronius, GFG Bezemer, AC Bostroem, A Carusi, S Coecke, R Concha, EP Daskalopoulos, F Debernardi, E Edrosa, SW Edwards, J Filipovska, N Garcia-Reyero, FNE Gavins, S Halappanavar, AJ Hargreaves, HT Hogberg, MT Huynh, D Jacobson, J Josephs-Spaulding, YJ Kim, HJ Kong, CE Krebs, A Lam, B Landesmann, A Layton, YO Lee, DS Macmillan, A Mantovani, L Margiotta-Casaluci, M Martens, R Masereeuw, SA Mayasich, LM Mei, H Mortensen, A Munoz Pineiro, P Nymark, E Ohayon, J Ojasi, A Paini, N Parissis, S Parvatam, F Pistollato, M Sachana, JB Sørli, KM Sullivan, J Sund, S Tanabe, K Tsaioun, M Vinken, L Viviani, J Waspe, C Willett, C Wittwehr.
ALTEX 39 (2), 322–335. Link

(2022)Thromboinflammation in coronavirus disease 2019: The clot thickens

R Iffah, FNE Gavins

British Journal of Pharmacology 179, 2100-2107. Link

(2021)Neutrophils and Platelets: Immune Soldiers Fighting Together in Stroke Pathophysiology

J Ansari, FNE Gavins

Biomedicines 199 (12),1945. Link

(2021)The Resolution Mediator Annexin A1 Affords Protection Against Thromboinflammation

FNE Gavins

Blood 138 (Supplement 1), 1056-1056. Link

(2021)The impact of thrombo‐inflammation on the cerebral microcirculation

J Ansari, FNE Gavins

Microcirculation 28 (3), e12689. Link

(2021) Targeting the AnxA1/Fpr2/ALX pathway regulates neutrophil function, promoting thromboinflammation resolution in sickle cell disease

J Ansari, EY Senchenkova, SA Vital, Z Al-Yafeai, G Kaur, EM Sparkenbaugh, AW Orr, R Pawlinski, RP Hebbel, DN Granger, P Kubes, FNE Gavins

Blood 137 (11), 1538-1549. Link

(2021) A Biomicrofluidic Screening Platform for Dysfunctional Endothelium‐Targeted Nanoparticles and Therapeutics

S Bazban-Shotorbani, FNE Gavins, K Kant, M Dufva, N Kamaly

Advanced NanoBiomed Research, 2100092.z Link

(2021) Long-lived lanthanide emission via a pH-sensitive and switchable LRET complex

T Boltersdorf, FNE Gavins, NJ Long

Chemical Science. Link

(2021) Targeting AnxA1/formyl peptide receptor 2 pathway affords protection against pathological thrombo-inflammation

SA Vital, EY Senchenkova, J Ansari, FNE Gavins

Cells 9 (11), 2473. Link

(2020) Bioinformatics analysis of gut microbiota and CNS transcriptome in virus-induced acute myelitis and chronic inflammatory demyelination; Potential Association of Distinct Bacteria With CNS IgA Upregulation

S Omura, F Sato, AM Park, M Fujita, S Khadka, Y Nakamura, A Katsuki, K Nishio, FNE Gavins, I Tsunoda

Frontiers in immunology 11, 1138. Link

(2020) Targeting of Formyl Peptide Receptor 2 for in vivo imaging of acute vascular inflammation

T Boltersdorf, J Ansari, EY Senchenkova, J Groeper, D Pajonczyk, SA Vital, G Kaur, JS Alexander, T Vogl, U Rescher, NJ Long, FNE Gavins

Theranostics 10 (15), 6599. Link

(2019) Endogenous specialized Proresolving mediator profiles in a novel experimental model of lymphatic obstruction and intestinal inflammation in African Green monkeys

F Becker, E Romero, J Goetzmann, DL Hasselschwert, B Dray, J Vanchiere, J Fontenot, JW Yun, PC Norris, L White, M Musso, CN Serhan, JS Alexander, FNE Gavins

The American journal of pathology 189 (10), 1953-1972. Link

(2019) Dynamic gut microbiome changes following regional intestinal lymphatic obstruction in primates

F Becker*, FNE Gavins*, J Fontenot, P Jordan, JY Yun, R Scott, PR Polk, RE Friday, M Boktor, M Musso, E Romero, S Boudreaux, J Simmons, DL Hasselschwert, JE Goetzmann, J Vanchiere, U Cvek, M Trutschl, P Kilgore, JS Alexander

Pathophysiology 26 (3-4), 253-261. *Contributed equally. Link

(2019) Novel role for the AnxA1-Fpr2/ALX signaling axis as a key regulator of platelet function to promote resolution of inflammation

EY Senchenkova, J Ansari, F Becker, SA Vital, Z Al-Yafeai, M Sparkenbaugh, R Pawlinski, KY Stokes, JL Carroll, A Dragoi, CX Qin, RH Ritchie, H Sun, HH Cuellar-Saenz, MR Rubinstein, YW Han, AW Orr, M Perretti, DN Granger, FNE Gavins

Circulation 140 (4), 319-335. Link

(2019) Novel Role of T Cells and IL-6 (Interleukin-6) in angiotensin II–induced microvascular dysfunction

EY Senchenkova, J Russell, A Yildirim, DN Granger, FNE Gavins

Hypertension 73 (4), 829-838. Link

(2019) Development, characterisation and in vitro evaluation of lanthanide-based FPR2/ALX-targeted imaging probes

T Boltersdorf, J Ansari, EY Senchenkova, L Jiang, AJP White, M Coogan, FNE Gavins*, NJ Long*

Dalton Transactions 48 (44), 16764-16775. *Contributed equally. Link

(2018) The isothiocyanate sulforaphane modulates platelet function and protects against cerebral thrombotic dysfunction

S Gillespie, PM Holloway, F Becker, F Rauzi, SA Vital, KA Taylor, KY Stokes, MEmerson, FNE Gavins

British Journal of Pharmacology 175 (16), 3333-3346. Link

(2018) Metallothionein I as a direct link between therapeutic hematopoietic stem/progenitor cells and cerebral protection in stroke

HK Smith, S Omura, SA Vital, F Becker, EY Senchenkova, G Kaur, I Tsunoda, SM Peirce, FNE Gavins

The FASEB Journal 32 (5), 2381-2394. Link

(2018) Therapeutic potential of annexin A1 in ischemia reperfusion injury

J Ansari, G Kaur, FNE Gavins

International journal of molecular sciences 19 (4), 1211. Link

(2018) Sickle cell disease: a malady beyond a hemoglobin defect in cerebrovascular disease

J Ansari, YE Moufarrej, R Pawlinski, FNE Gavins

Expert review of hematology 11 (1), 45-55. Link

(2017) Mast cells mediate early neutrophil recruitment and exhibit anti‐inflammatory properties via the formyl peptide receptor 2/lipoxin A4 receptor

EL Hughes, F Becker, RJ Flower, JC Buckingham, FNE Gavins

British journal of pharmacology 174 (14), 2393-2408. Link

(2017) Downregulation of CX3CR1 ameliorates experimental colitis: evidence for CX3CL1-CX3CR1-mediated immune cell recruitment

F Becker, C Holthoff, C Anthoni, E Rijcken, JS Alexander, FNE Gavins, HU Spiegel, N Senninger, T Vowinkel

International journal of colorectal disease 32 (3), 315-324. Link

(2017) Sulforaphane induces neurovascular protection against a systemic inflammatory challenge via both Nrf2-dependent and independent pathways

PM Holloway, S Gillespie, F Becker, SA Vital, V Nguyen, JS Alexander, PC Evans, FNE Gavins

Vascular pharmacology 85, 29-38. Link

(2016) Formyl-Peptide Receptor 2/3/Lipoxin A4 Receptor Regulates Neutrophil-Platelet Aggregation and Attenuates Cerebral Inflammation: Impact for Therapy

SA Vital, F Becker, PM Holloway, J Russell, M Perretti, DN Granger, FNE Gavins

Circulation 133 (22), 2169-2179. Link

(2016) Modeling ischemic stroke in vitro: status quo and future perspectives

PM Holloway, FNE Gavins

Stroke 47 (2), 561-569. Link

(2015) Both MC1 and MC3 Receptors Provide Protection From Cerebral Ischemia-Reperfusion–Induced Neutrophil Recruitment

PM Holloway, PF Durrenberger, M Trutschl, U Cvek, D Cooper, AW Orr, M Perretti, SJ Getting, FNE Gavins

Arteriosclerosis, thrombosis, and vascular biology 35 (9), 1936-1944. Link

(2015) Critical differences between two classical surgical approaches for middle cerebral artery occlusion-induced stroke in mice

HK Smith, JM Russell, DN Granger, FNE Gavins

Journal of Neuroscience Methods 249, 99-105. Link

(2015) Targeting formyl peptide receptor 2 reduces leukocyte‐endothelial interactions in a murine model of stroke

HK Smith, CD Gil, SM Oliani, FNE Gavins

The FASEB Journal 29 (5), 2161-2171. Link

(2015) 99m Tc SPECT imaging agent based on cFLFLFK for the detection of FPR1 in inflammation

GJ Stasiuk, PM Holloway, C Rivas, W Trigg, SK Luthra, VM Iveson, FNE Gavins*, NJ Long*

Dalton Transactions 44 (11), 4986-4993. *Contributed equally. Link

(2015) PARP-14 combines with tristetraprolin in the selective posttranscriptional control of macrophage tissue factor expression

MB Iqbal, M Johns, J Cao, Y Liu, SC Yu, GD Hyde, MA Laffan, FP Marchese, SH Cho, AR Clark, FNE Gavins, KJ Woollard, PJ Blackshear, N Mackman, JL Dean, M Boothby, DO Haskard

Blood. 124 (24), 3646-3655. Link

(2014) ICAM-2 regulates vascular permeability and N-cadherin localization through ezrin-radixin-moesin (ERM) proteins and Rac-1 signalling

V Amsellem, NH Dryden, R Martinelli, F Gavins, LO Almagro, GM Birdsey, DO Haskard, JC Mason, P Turowski, AM Randi

Cell Communication and Signaling 12 (1), 1-14. Link

(2013) Role and interactions of annexin A 1 and oestrogens in the manifestation of sexual dimorphisms in cerebral and systemic inflammation

EL Hughes, PO Cover, JC Buckingham, FNE Gavins

British journal of pharmacology 169 (3), 539-553. Link

(2013) Gd 3+ cFLFLFK conjugate for MRI: a targeted contrast agent for FPR1 in inflammation

GJ Stasiuk, H Smith, M Wylezinska-Arridge, JL Tremoleda, W Trigg, SK Luthra, VM Iveson, FNE Gavins*, NJ Long*

Chemical Communications 49 (6), 564-566. *Contributed equally. Link

(2013) Leukocyte recruitment in the brain in sepsis: involvement of the annexin 1‐FPR2/ALX anti‐inflammatory system

FNE Gavins, EL Hughes, NAPS Buss, PM Holloway, SJ Getting, JC Buckingam